Effect of aging on cellular mechanotransduction
نویسندگان
چکیده
منابع مشابه
Effect of aging on cellular mechanotransduction.
Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathoph...
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15 صفحه اولAging, Osteocytes, and Mechanotransduction
PURPOSE OF REVIEW The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. RECENT FINDINGS Severa...
متن کاملCellular basis of mechanotransduction.
Physical forces, such as those due to gravity, are fundamental regulators of tissue development. To influence morphogenesis, mechanical forces must alter growth and function. Yet little is known about how cells convert mechanical signals into a chemical response. This presentation attempts to place the potential molecular mediators of mechanotransduction within the context of the structural com...
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ژورنال
عنوان ژورنال: Ageing Research Reviews
سال: 2011
ISSN: 1568-1637
DOI: 10.1016/j.arr.2009.11.002